From June 2023 onward, Trellix will release a common detection package for all supported versions of Advanced Threat Defense (ATD) and Intelligent Sandbox (IS). This common detection package is a single unifying detection package file and replaces the previous version-specific detection packages. To accept the new common detection package, you must either upgrade to version 5.2.2 or follow the instructions in KB96550 to install a patch on ATD 4.x or IS 5.0.0.11/5.2.0.16.
For more details on the change, the patch, and how to install the patch, see KB96550 - How to enable support for the Intelligent Sandbox and Advanced Threat Defense common detection package.